Program CTC-RG2021

Primary Sponsor

Time (BST) Time (CDT) Title Speaker Affiliation
3:00 pm 9:00 am Welcome and Introduction Hager Reinmar University of Manchester, UK
3:15 pm 9:15 am Genetics, Omics, and Live FAIR+ Data Reanalysis using Workbooks and GeneNetwork Williams Robert University of Tennessee Health Science Center, USA
3:30 pm9:30 amGenetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cellsBaker ChristopherThe Jackson Laboratory, USA
3:45 pm9:45 amNIDA center for genetic studies of drug abuse in outbred ratsPalmer AbrahamUniversity of California San Diego, USA
4:00 pm10:00 amIdentification of regulatory landscape in multiple brain regions of outbred heterogeneous stock ratsMunro DanielUniversity of California San Diego, USA
4:15 pm10:15 amBREAK
4:30 pm10:30 amDiscovery of Heritable Cancer Risk Genes Using Diversity Outbred F1 mice That Express HER2/Neu OncogeneWei Wei-ZenWayne State University, USA
4:45 pm10:45 amNatural genetic variation alters Alzheimer's-related gene expression modules in miceWells AnnThe Jackson Laboratory, USA
5:00 pm11:00 amA BALB/c reduced complexity cross identifies Zhx2 as a candidate underlying oxycodone metabolite brain concentration and state-dependent learningBeierle JacobBoston University, USA
5:15 pm11:15 amGenetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity crossBryant CamronBoston University, USA
5:30 pm11:30 amBREAK
5:45 pm11:45 amRegulation of protein abundance in genetically diverse mouse populationsKeele GregThe Jackson Laboratory, USA
6:00 pm12:00 pmGenetic dissection of the pluripotent proteomeAydin SelcanThe Jackson Laboratory, USA
6:15 pm12:15 pmPower and precision: Evaluation and recommendations of quantitative trait analysis methods for RNA expression levels in the Hybrid Rat Diversity PanelPattee JackUniversity of Colorado, USA
6:30 pm12:30 pmTranscriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Novel Genetic Regulatory Mechanisms Relevant for Obesity in HumansSolberg Woods LeahWake Forest University, USA
6:45 pm12:45 pmBREAK
7:00 pm1:00 pmBREAK
7:15 pm1:15 pmInvestigating the gut-brain axis in 4,006 P50 Heterogeneous Stock ratsBaud AmelieCentre for Genomic Regulation, Spain
7:30 pm1:30 pmDifferential Mechanisms Dictate Cholesterol Levels in Chow-fed Versus High fat diet-fed MiceCousineau CodyUniversity of Michigan, USA
7:45 pm1:45 pmBREAK
8:00 pm2:00 pmCANCELLED Connecting DCX, COMT and FMR1 in Social Behavior and Cognitive Impairment Manoj DevikaDelprato lab, USA 
8:00 pm2:00 pmA general hidden Markov model for multi-parent populationsBroman KarlUniversity of Wisconsin - Madison
8:15 pm2:15 pmSodium accumulation and blood capillary rarefaction in the skin predisposes spontaneously hypertensive rats to salt sensitive hypertensionPravenec Michal Czech Academy of Sciences, Czech Republic
8:15 pm2:15 pmIntegrated transcriptomic analysis reveals unique NASH progression in Leptin deficient ratsZhu XianminShanghai Tech University, China
8:30 pm2:30 pmIdentification of novel QTL linked to the metabolic syndrome in the Berlin Fat MouseDelpero Manuel Humboldt University Berlin, Germany
8:30 pm2:30 pmProjecting human and rat GWAS into network space identifies shared genetic control of BMI and heightLeger BrittanyUniversity of California San Diego, USA
8:45 pm2:45 pmHigh-fat diet generally exacerbates, but is sometimes protective against, cognitive dysfunction in female AD mice depending on genetic backgroundDunn AmyThe Jackson Laboratory, USA
9:00 pm3:00 pmEnd of Day 1
Time (BST) Time (CDT) Title Speaker Affiliation
3:00 pm 9:00 am Congenic Mapping and Comparative Genomics of Rat Mammary Carcinoma Susceptibility Locus, Mcs3 Duderstadt Emily University of Louisville, USA
3:15 pm 9:15 am Integrating the Collaborative Cross genetic reference panel with Chd8 haploinsufficiency to discover mechanisms regulating behavioral heterogeneity. Tabbaa Manal University of Southern California, USA
3:30 pm9:30 amGenetic Analysis of the "Levin Rat" - a Rodent Model of Diet-Sensitive ObesityGoffer YossefColumbia University, USA
3:45 pm9:45 amPolymorphic SNPs, short tandem repeats and structural variants cause differential gene expression among inbred C57BL/6 and C57BL/10 substrainsMortazavi MiladUniversity of California San Diego, USA
4:00 pm10:00 amBREAK
4:15 pm10:15 amHuman-GWAS and rat Mcs1b nominated MIER3 is a causal breast cancer susceptibility geneSamuelson DavidUniversity of Louisville, USA
4:30 pm10:30 amGenetic analysis of multiple measures of locomotor activity in 2,325 outbred Heterogeneous Stock ratsChitre ApurvaUniversity of California San Diego, USA
4:45 pm10:45 amKeratinocyte-associated protein 3 impacts eating behavior and adiposity differentially based on environmental influencesSzalanczy AlexandriaWake Forest University, USA
5:00 pm11:00 amGenetically diverse mouse embryonic stem cells enable inference of genetic regulatory structureKuffler LaurenThe Jackson Laboratory, USA
5:15 pm11:15 amBREAK
5:30 pm11:30 amGenetic mapping of multiple metabolic traits identifies novel genes for adiposity and insulin secretory capacity in outbred ratsLe Thu HongUniversity College London, UK
5:45 pm11:45 amA wild-derived mutator locus drives germline mutation spectrum differences in a genetically diverse murine familyHarris KelleyUniversity of Washington, USA
6:00 pm12:00 pmAutomated high-throughput analysis of gait and whole body posture in JAX-KOMP2 pipeline identifies regulators of motor functionsSabnis GautamThe Jackson Laboratory, USA
6:15 pm12:15 pmBREAK
6:30 pm12:30 pmBREAK
6:45 pm12:45 pmGenetic basis for unilateral renal agenesis in heterogenous stock ratsLeal-Gutierrez Joel DavidUniversity of California San Diego, USA
7:00 pm1:00 pmGenome-wide association study (GWAS) of complex behavioral traits in larval zebrafish Xu JialeUniversity of California San Francisco, USA
7:00 pm1:00 pmHigh-throughput genotyping of zebrafish enables GWAS in outbred EKW populationPolesskaya OksanaUniversity of California San Diego, USA
7:15 pm1:15 pmBREAK
7:30 pm1:30 pmRat Genome Database (RGD): A multi-species resource to explore complex diseaseSmith JenniferMedical College of Wisconsin, USA
7:45 pm1:45 pmRGD - Multi-Ontology Enrichment Tool (MOET) - A Bioinformatics Tool for Ontology Analysis Across Multiple Species and Ontologies Vedi  Mahima Medical College of Wisconsin, USA 
7:45 pm1:45 pmRGD - Rat strain updates at the Rat Genome Database (RGD)Wang Shur-JenMedical College of Wisconsin, USA
8:00 pm2:00 pmRGD - Quantitative Data Curation for the Hybrid Rat Diversity Panel (HRDP) in RGD’s PhenoMiner Database Kwitek  AnneMedical College of Wisconsin, USA 
8:00 pm2:00 pmRGD - Comparison of genomic variants discovery in HRDP inbred rat strains with two rat genome referencesTutaj MonikaMedical College of Wisconsin, USA
8:15 pm2:15 pmRGD - Rat Reference mRatBN7.2 Update and CurationDemos WendyMedical College of Wisconsin, USA
8:30 pm2:30 pmRGD DiscussionKwitek AnneMedical College of Wisconsin, USA
9:00 pm3:00 pmEnd of Day 2
Time (BST) Time (CDT) Title Speaker Affiliation
3:00 pm 9:00 am Bayesian modeling of skewed X inactivation in genetically diverse mice reveals a novel Xce allele and hidden properties of embryonic composition Valdar William University of North Carolina Chapel Hill, USA
3:15 pm 9:15 am Genetics and sex, but not gene by diet interactions, contribute to metabolic and behavioral responses to high fat diet in heterogeneous stock rats Deal Aaron Wake Forest University, USA
3:30 pm9:30 amOpen field nocifensive behavior assayHession LeinaniThe Jackson Laboratory, USA
3:45 pm9:45 amGenetic Architecture of Heart Mitochondrial Proteome influencing Cardiac HypertrophyChella Krishnan KarthickeyUniversity of Cincinnati, USA
4:00 pm10:00 amBREAK
4:15 pm10:15 amGenome-wide association study identifies Taar1 as a candidate gene underlying the response to a Pavlovian reward cuesMeyer PaulUniversity at Buffalo, USA
4:30 pm10:30 amLow-Coverage Whole Genome Sequence Genotyping Pipeline for Peromyscus CalifornicusChen DenghuiUniversity of California San Diego, USA
4:45 pm10:45 ammRatBN7 ushers in a new era of rat genomics and genetics researchChen HaoUniversity of Tennessee Health Science Center, USA
5:00 pm11:00 amBREAK
5:15 pm11:15 amBREAK
5:30 pm11:30 amQuantitative trait locus implicates expression of a mismatch repair protein in STR expansion propensity in miceMaksimov MikhailUniversity of California San Diego, USA
5:45 pm11:45 amGenetic Architecture of Transcript Levels in RatsIm Hae KyungUniversity of Chicago, USA
6:00 pm12:00 pmGenetics of Unsupervised Learning Based Mouse Behavior SpaceKumar VivekThe Jackson Laboratory, USA
6:15 pm12:15 pmMulti-omics, more than the sum of its partsVacher CoraIllumina, UK
6:30 pm12:30 pmBREAK
6:45 pm12:45 pmBREAK
7:00 pm1:00 pmIdentifying Protein Complexes Binding to Risk Functional Variants in the Uromodulin PromoterMcBride Martin University of Glasgow, UK
7:00 pm1:00 pmA novel µ-opioid receptor transgenic Cre rat: Cellular and behavioral characterizationSaunders ThomUniversity of Michigan, USA
7:15 pm1:15 pmComparing different quantification methods for delayed reward discountingMitchell Suzanne Oregon Health & Science University, USA
7:15 pm1:15 pmStrain Nomenclature Curation: From Repository to IMSR to MGIPerry MichelleThe Jackson Laboratory, USA
7:30 pm1:30 pmThe Bayesian Network Webserver: A tool for network modeling of system genetics dataZiebarth Jesse University of Tennessee Health Science Center, USA 
7:30 pm1:30 pmInvestigating the effect of a large deletion in intron 8 of the Bbs7 gene on the Berlin Fat Mouse phenotypeKrause FlorianHumboldt University Berlin, Germany
7:45 pm1:45 pmBREAK
8:00 pm2:00 pmDominance genetic effects on complex traits in pigs, rats and mice are associated with trans-acting dominance gene expression effectsCui LeileiUniversity College London, UK 
8:00 pm2:00 pmPreliminary Analysis of Cocaine Sensitivity in a Genome-Wide Association Study Involving Heterogeneous Stock RatsRakowski ElizabethUniversity at Buffalo, USA
8:15 pm2:15 pmGWAS on socially acquired nicotine IVSA in heterogeneous stock rats highlights genes implicated in human smoking behaviorWang Tengfei University of Tennessee Health Science Center, USA 
8:15 pm2:15 pmGenome-wide association study on behaviors in an open field in outbred rats identifies multiple loci implicated in psychiatric disordersGunturkun HakanUniversity of Tennessee Health Science Center, USA
8:30 pm2:30 pmQTL mapping in Collaborative Cross mice reveals candidate loci modulating severe coronavirus diseaseRisemberg EllenUniversity of North Carolina Chapel Hill, USA
8:45 pm2:45 pmPrize announcement and thanksHager ReinmarThe University of Manchester, UK
8:45 pm2:45 pmCTC and Rat Genomics in Colorado 2022Saba LauraUniversity of Colorado, USA
9:00 pm3:00 pmClose of meeting