5th Annual Meeting of the Complex Trait Consortium
May 6-10, 2006 Chapel Hill, North Carolina.

Overview Keynotes Registration List of registrants Abstract submission Hotel reservation Travel information Full Program

Overview

• The CTC (Complex Trait Consortium) is open to all those interested in or working on the identification of gene networks and allelic variants that modulate complex phenotypes in diverse environments (geneticists, molecular biologists, bioinformaticists, statisticians, modelers, computer scientists, etc.). Along with the major large-scale genomic sequencing projects, QTL mapping, quantitative and systems genetics have undergone a major revolution in the last decade. Progress in the next decade promises to be even more rapid and the prospects for exploring and investigating the complex interactions between gene variants, disease, and the environment will be significantly improved. Essentially all human diseases are complex since their range of prevalence, severity and outcome is determined by the interaction of many genes and environmental factors. Representative areas of interest at the annual meeting include statistical and computational tools, complex trait resources, use of humans and model organisms for complex or polygenic trait analysis, systems genetics, genetical genomics, population genetic variation associated with phenotypic variation, and QTLs. There will be cash prizes for best student and postdoc presentations (both platform talks and posters).

Keynotes

• David A. Schwartz, director of National Institute of Environmental Health Sciences (NIEHS).
• Jean-Louis Guenet, Institute Pasteur.

Registration

• Online registration form is available here
  After registering, you will be directed to a secure site to pay the registration fee ($125). Registration covers all meeting expenses, including a reception dinner on May 6th, breakfast and lunch on May 7th and 8th, and breakfast, lunch and the conference banquet on May 9th. Alternatively, registration can be paid by mailing a check made out to David Threadgill-CTC06 Meeting, Department of Genetics, CB#7264, University of North Carolina, Chapel Hill, NC 27599.

List of registrants

• List of Attendees

Abstract submission

• The abstract deadline is April 20th. Please send abstracts for talks and poster presentations to either David Threadgill (dwt@med.unc.edu) or Jef French (french@niehs.nih.gov) by the date to ensure they are included in the meeting book.

Hotel reservation

• A block of rooms has been reserved at two hotels near The Friday Center conference site. Please register directly with them by the deadline to obtain the negotiated rates. Other near-by hotels are also listed below. Numbers correspond to their location on the Chapel Hill map under the travel information section.

  Conference hotels:

  1. Courtyard by Mariott

  100 Marriott Way

  Chapel Hill, North Carolina 27517 USA

  Phone: 1-919-883-0700

  Fax: 1-919-883-0701

  http://marriott.com/property/propertypage.mi?marshaCode=RDUCH

  A block of rooms has been reserved at a special rate of $119 (single/double) per night plus tax. Complimentary high speed wireless internet access is provided. This special rate is available until April 15, 2006. Please be certain that you have guaranteed your reservation at the Courtyard in Chapel Hill with your credit card by April 15th, 2006. Please indicate that you are attending the Complex Trait 5th Annual Meeting at the Friday Center. After April 15th, 2006, the regular rates will apply. Online booking for this rate is NOT available, please call the hotel directly. This hotel is within a short walk of the Friday Center and also provides local shuttle service. City bus service is free in Chapel Hill and there is a major transfer point across the street.

  2. Best Western University Inn

  1310 Raleigh Road

  Chapel Hill, NC 27515-2118

  Phone: 1-919-932-3000

  Fax: 1-919-968-6513

  http://book.bestwestern.com/bestwestern/productInfo.do?propertyCode=34086#null

  A block of rooms has been reserved at a special rate of $79/82 (single/double) per night plus tax. Complimentary high speed internet access is is provided. This special rate is available until April 5, 2006. Please be certain that you have guaranteed your reservation at the Best Western University Inn in Chapel Hill with your credit card by April 5th, 2006. Please indicate that you are attending the Complex Trait Consortium meeting at the Friday Center. After April 5th, 2006, the regular rates will apply. Online booking for this rate is NOT available, please call the hotel directly. This hotel is within walking distance of the Friday Center (< 1 mile) and also provides local shuttle service. City bus service is free in Chapel Hill.

  Additional hotels:

  3. Carolina Inn

  211 Pittsboro St, Chapel Hill, NC 27599

  Phone: 1-919-933-2001

  http://www.carolinainn.com/

  A historic hotel located in downtown Chapel Hill, NC on the campus of The University of North Carolina. Historic charm, modern amenities, gracious service, and memorable food blend beautifully at The Carolina Inn, a AAA Four Diamond Award Winner & Member of Historic Hotels of America.

  4. Siena Hotel

  1505 E Franklin St, Chapel Hill, NC 27514

  Phone: 1-800-223-7379

  http://www.sienahotel.com/

  The Siena Hotel is North Carolina's premier European boutique hotel.  Inspiration for this luxury, Four Diamond hotel is taken from the art and beauty of Italy. Step through the doors of this sumptuous Tuscan villa into the marble-lined lobby, lined with majestic columns and filled with freshly-cut flowers.

  5. Sheraton Hotel

  1 Europa Dr, Chapel Hill, NC 27517

  Phone: 1-919-968-4900

  http://www.sheratonchapelhill.com/

  Free local shuttle service. Wireless internet availble in lobby.

  6. Holiday Inn Express

  6119 Farrington Road, Chapel Hill, NC 27514

  Phone: 1-800-HOL-IDAY

  Located about 1 mile from conference site. Free high-speed wireless internet. Free local shuttle service.

Travel information

• The 5th Annual Meeting of the Complex Trait Consortium will be held at the Friday Center (http://www.fridaycenter.unc.edu) at the University of North Carolina-Chapel Hill (http://www.unc.edu). Chapel Hill, North Carolina is located near the Raleigh-Durham International Airport (RDU) (http://www.rdu.com), which is served by all major US airlines along with direct flights on American Airlines from London Gatwick.
  
  The Friday Center (+1-866-441-3683) is located at 100 Friday Center Drive, approximately three miles east of the UNC-Chapel Hill campus, just off Highway 54 East (Raleigh Road). The Center is a short distance from Interstate 40 (from Raleigh, I-40 exit 273A; from Greensboro, I-40 exit 273). The Raleigh-Durham International Airport on I-40 is located 15 miles from the Center and is readily accessable by taxi (~$20 each way).
  

5 th Annual Meeting of the Complex Trait Consortium

Full Program

Saturday, May 6

16:00 Registration opens, Atrium

17:00 Collaborative Cross Discussion and Update, Redbud Room A/B

Robert Williams, Gary Churchill, Richard Mott, Fuad Iraqi, Ken Manly, Elissa Chesler, David Threadgill

18:00 Reception, Atrium

20:00 Adjourn

Sunday, May 7

8:00 Breakfast, Atrium

9:00 Welcome, Grumman Auditorium

Jef French and David Threadgill

9:15 Keynote Lecture

J Evans The permeation of medicine by genetics; from Gucci to Wal-mart?

10:15 Session 1: Resource Populations for Complex Trait Analysis

Chair: Jef French

K Manly (1) CCDB: database for the collaborative cross at Oak Ridge National Laboratory

F Iraqi (2) Body Weight, Packed Cell Volume, Maturity Age, Litter Size and Mouse Survival at Pre and Post-Weaning traits of the Collaborative Cross Mice

10:45 Break and Poster Session 1 preview, Atrium

11:30 Session 1 continued

RW Williams (3) Behavioral phenotypes in the collaborative cross mouse

E Chesler (4) Gene to phenotype network applications and the 8-Way collaborative cross: progress, applications and future potential

W Valdar (5) Genome-wide QTL-mapping of multiple complex phenotypes in HS mice

S Shifman (6) A high resolution single nucleotide polymorphism genetic map of the mouse genome

12:30 Lunch, Trillium Room (lunch ticket required)

13:30 Session 2: Mapping and Cloning QTLs

Chair: Fernando Pardo-Manuel de Villena

N Navarro (7) Mapping shape loci of the mouse mandible using a heterogeneous stock

J-F Bureau (8) Fine mapping of the Tmevp3 locus

G de Haan (9) Identification of a chromosome 18 QTL regulating genes involved in chromatin remodelling and hematopoietic stem cell pool size

Come See My Poster Introductions

15:00 Break and Poster Session 1, Atrium

R Alberts (10) A verification pipeline and an UCSC Genome Browser track for the probe sequences of Affymetrix genome arrays

Y-L Chang (11) An approximate Bayesian approach for QTL estimation

D Delano (12) Expression QTL as a tool for the filtering of clinical QTL candidate genes

C Duarte (13) Combining QTL analysis and Bayesian Network discovery methods to determine genetic relationships in a micorarray/marker dataset

D Gatti (14) Examination of genetic networks that regulate gene expression in liver using complex trait analysis

K Gaulton (15) A computational system to select candidate genes for complex human traits

I Hoeschele (16) Gene network inference in genetical genomics experiments using structural equation modeling

J Liu (17) Genome-wide identification of differentiating SNPs

I Lu (18) From genotype to phenotype in the mouse genome informatics (MGI) database: integrating quantitative trait loci with the annotated mouse genome

A Manichaikul (19) Identifying quantitative trait loci and their interactions by model selection

X Montagutelli (20) Influence of inaccuracy of phenotype measurement of the identification of QTLs

R Overall (21) Hippocampal gene networks in BXD mice

L Saba (22) Colorado INIA Informatics Website: consolidation of microarray data, analysis, and interpretation

K Shockley (23) Gene expression analysis of mouse chromosome substitution strains

S-W Tsaih (24) Linear model genome scans for expression QTL analysis

T Yang (25) A visualization framework for high-dimensional data

16:30 Session 2 continued

T Mersha (26) Development of NIR spectroscopy for the identification of transposon-tagged QTL kernel composition mutants

D Prows (27) Genetic analysis of hyperoxia-induced acute lung injury survival in mice

R Korstanje (28) Quantitative trait locus analyses for urinary albumin in crosses between B6 and A/J inbred mice: Identification of an ApoE dependent pathway

X Wang (29) Using human-mouse comparative genomics to find new genes regulating plasma HDL cholesterol Levels

17:45 Software Demo and Tutorial, Rosebud Room A/B

R von Smith (30) J/qtl: A graphical user interface for QTL analysis

19:45 Adjourn and dinner on your own

Monday, May 7th

8:00 Breakfast, Atrium

9:00 NIGMS National Center for Systems Biology, Grumman Auditorium

G Churchill (31) Genome dynamics

9:30 Session 3: Disease Modifiers

Chair: Daniel Pomp

F Wheeler (32) Investigation of Tnni3k, a novel putative Troponin I kinase, as a heart failure modifier gene in a murine model of cardiomyopathy

R Li (33) A structural modeling approach to identification of regulatory genes for complex traits

K Hunter (34) Gen[om/et]ics Analysis of Metastatic Efficiency

B Mock (35) Pctr loci encode efficiency alleles that act additively to suppress the generation of plasma cell tumors

10:30 Break and Poster Session 2 preview, Atrium

11:30 Session 3 continued

H Nagase (36) Diplotype problems of the low-penetrance cancer susceptibility gene

K Reilly (37) Nerve sheath tumor resistance QTLs 1 and 2 increase tumor resistance by different mechanisms: using chromosome substitution strains to dissect tumor resistance

N Crawford (38) Identification and characterization of Anakin, a novel metastasis efficiency modifying gene, through gen[om/et]ic analysis

W Ferguson (39) Molecular changes associated with mammary tumor progression in a PyVmT-based mouse model

12:30 Lunch, Trillium Room (lunch ticket required)

13:30 Session 4: Improving QTL Localization

Chair: Don Cook

B Payseur (40) Prospects for haplotype-based mapping across classical inbred mouse strains

G Brockmann (41) Fine mapping of mouse obesity QTLs by dense SNP data

T Vision (42) Improving quantitative trait loci mapping resolution in experimental crosses by the use of genotypically selected samples

Come See My Poster Introductions

15:00 Break and Poster Session 2, Atrium

A Baran (43) Characterization and mechanism of action of the Modifier of Min 2 (Mom2)

E Blankenhorn (44) A genetic analysis of sex chromosomal and sex hormonal influences on EAE

A Bleich (45) Analysis of Cd14 as a potential modifier gene in experimental IBD

L Cort (46) The genetic control of early traits in rat EAE

W DuBois (47) The effects of conventional vs SPF environments on the induction of plasmacytomas in BALB/cAnPt mice

C Eversley (48) Identifying resistance modifiers of azoxymethane-induced colon cancer

L Fernandez (49) An N-ethyl-N-nitrosourea mutagenesis screen identifies the proximal end of chromosome 1 as a candidate region for murine cardiomyopathy

H Kim (50) A combined cross analysis reveals an abundance of cross-specific QTL

B Llamas (51) Chromosome Y alters morphology and cardiac function in C57BL/6J mice

E Richer (52) Salmonella Typhimurium mouse resistome explored by chemical mutagenesis

M Roy (53) Complexity in the host response to Salmonella Typhimurium infection revealed through the study of AcB and BcA recombinant congenic strains

V Sancho-Shimizu (54) The effect of genetic background in an intersubspecific mouse cross: the candidacy of Tlr5 in Salmonella susceptibility of MOLF/Ei mice

L Siracusa (55) Novel modifier loci influence intestinal and colorectal polyposis in the C3H/HeJ genome

M Southard-Smith (56) Genetic interactions that modulate the penetrance and severity of aganglionosis in the Sox10 Dom model of Hirschsprung disease

F Wheeler (57) Investigation of Tnni3k, a novel putative Troponin I kinase, as a heart failure modifier gene in a murine model of cardiomyopathy

Q Xing (58) A complex genetic system regulates resistance to herpes simplex virus

D Yan (59) Genetic background influences fluoride’s effects on bone biology

16:30 Session 4 continued

K Broman (60) Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus

F Zou (61) Is the MLE of the QTL position truly optimal?

I Rusyn (62) Toxicogenetic dimension in studies of the mechanisms of liver injury

B Aronow (63) How big is the transcriptomic dark matter universe? Random primer labeling reveals high level accumulation of non-poly-adenylated mRNAs encoding critical genes

17:45 Software Demo and Tutorial, Rosebud Room A/B

RW Williams (64) GeneNetwork and WebQTL tutorial: An on-line systems genetics pilot project

19:45 Adjourn and dinner on your own

Tuesday, May 9

8:00 Breakfast, Atrium

9:00 Keynote Lecture, Grumman Auditorium

J-L Guenet (65) Quantitative trait locus analyses in the mouse: promise for the future

10:00 Session 5: eQTL Analysis

Chair: David Threadgill

J Gelfond (66) Proximity model for expression quantitative trait loci (eQTL) detection

A Palmer (67) A combined QTL/eQTL approach identifies Casein kinase 1 epsilon (Csnk1e) as a candidate gene for stimulant sensitivity in mice and humans

10:30 Break and Poster Session 3 preview, Atrium

11:30 Session 5 continued

RBH Williams (68) Microarray normalization profoundly influences identity of linkage in expression genetics studies

W Zou (69) Transcriptional regulatory pattern in yeast revealed through eQTL mapping

J Yu (70) Association mapping accounting for multiple levels of relatedness

J Peirce (71) How replicable are mRNA expression QTLs?

12:30 Lunch, Trillium Room (lunch ticket required)

13:30 Session 6: Complex Trait Analysis

Chair: Ivan Rusyn

B Bennett (72) Confirmation and fine mapping of ethanol sensitivity QTLs, and candidate gene testing in the LXS recombinant inbred mice

G Burgio (73) Genetic analysis of craniofacial architecture of the mouse using interspecific recombinant congenic strains (IRCS)

J Forejt (74) Construction and characterization of a complete panel of C57BL/6-Chr PWD inter-subspecies chromosome substitution strains

Come See My Poster Introductions

15:00 Break and Poster Session 3, Atrium

A Bolton (75) Utilization of whole genome SNP panels for efficient genetic mapping in the mouse

G Brockmann (76) Analysis of fatness associated QTLs by SNP data from inbred mouse lines

L Donahue (77) GH/IGF-I independent QTL for femoral volumetric BMD

J French (78) Genetic susceptibility to the loss of tumor suppressor gene function and cancer

A Hege (79) Toxicogenetic analysis of susceptibility to acetaminophen hepatotoxicity

F Ideraabdullah (80) The genetic architecture of the DDK syndrome: a parent-of-origin early embryonic lethal phenotype in the mouse

F Johannes (81) Mapping time-varying quantitative trait loci in time-to-failure experiments

V Kumar (82) Phychostimulant response profile of 34 inbred laboratory mouse strains

C Lin (83) Oligogenization of multigenic traits: using a cross between congenic and inbred strains to reduce complexity of quantitative traits

K Noben-Trauth (84) A hearing loss QTL on chr 10 in the LxS RI set

E Richfield (85) Stereological analysis of tyrosine-hydroxylase positive (TH +) and TH - neurons in the midbrain of 15 strains of mice

I Stylianou (86) Complex genetic architecture revealed by analysis of HDL in chromosome substitution strains and F 2 crosses

R Verdugo (87) Characterization of body weight QTL in a congenic strain of mouse chromosome 17

C Vinyard (88) Characterization of maximum jaw opening performance across 21 strains of inbred mice

H Vogel (89) Identification of a NmU2 receptor variant and its contribution to the obese phenotype of NZO mice

16:30 Session 6 continued

S Scherneck (90) Dissection of the diabetes susceptibility locus Nidd/SJL by breeding and characterizing of recombinant congenic lines

T Petryshen (91) QTL mapping studies of prepulse inhibition of startle, an endophenotype of schizophrenia, in mouse chromosome substitution strains

A Bleich (92) The microbial environment as a critical factor in animal research

K Shimomura (93) Mouse phenome project: a systematic comparison of circadian activity rhythms in 34 inbred mouse strains

17:30 CTC Organizational Meeting

18:00 Adjourn

18:45 Busses depart hotels

19:00 Banquet at Spice Street (cash bar)

201 S. Estes Drive, University Mall, Chapel Hill

Awards for best trainee presentations and posters

22:00 Busses return to hotels